This study investigates the spatiotemporal evolution of oil released during the Agia Zoni II shipwreck in the Saronic Gulf in 2017, employing the OpenOil module of the OpenDrift framework. The simulation integrates oceanographic and meteorological data to model the transport, weathering, and fate of spilled oil over a six-day period. Oil behavior is examined across key transformation processes, including dispersion, emulsification, evaporation, and biodegradation, using particle-based modeling and a comprehensive set of environmental inputs. The modeled results are validated against in situ observations and visual inspection data, focusing on four critical dates. The study demonstrates OpenOil’s potential for accurately simulating oil dispersion dynamics in semi-enclosed marine environments and highlights the significance of environmental forcing, vertical mixing, and shoreline interactions in determining oil fate. It concludes with recommendations for improving real-time response strategies in similar spill scenarios.