Achieving a circular and climate-neutral bioeconomy by 2050 requires not only high-quality recycling but also the large-scale integration of renewable carbon from biomass and atmospheric CO2 into material systems. Plastics represent the world’s largest and most rapidly growing carbon sink, positioning them as a critical intervention point for replacing fossil-based feedstocks with renewable alternatives. Because plastic packaging is one of the most visible material streams encountered by consumers in daily life, a transition toward sustainable, recyclable bioplastics has the potential to deliver both meaningful environmental benefits and strong societal impact, accelerating public awareness and acceptance of renewable carbon solutions. Poly(ethylene furanoate) (PEF)—a fully bio-based polyester synthesized from plant-derived 2,5-furandicarboxylic acid (FDCA) and monoethylene glycol (MEG)—offers a promising pathway toward more sustainable packaging due to its superior mechanical strength and gas-barrier performance relative to polyethylene terephthalate (PET). This study presents a cradle to grave life cycle assessment (LCA) of PEF resin production and PEF bottle applications, using industrially relevant, at-scale process data covering biomass feedstock conversion, polymer synthesis, packaging manufacture, use phase, and end of life. Bottle applications were selected as a focal point due to their technical maturity, commercial relevance, and suitability for direct comparison with incumbent PET systems. The results indicate that PEF can reduce greenhouse gas emissions by up to 71% and fossil resource depletion by 26% compared to PET at the resin level when biogenic carbon uptake is included. Moreover, the material’s enhanced functional properties enable lightweight, recyclable bottle designs with carbon footprint reductions of up to 88% for 500 mL formats under a baseline recycling rate scenario of 72%, with the remaining share directed to municipal solid-waste incineration with energy recovery. Sensitivity analyses reveal that virgin PEF maintains environmental advantages over PET even when PET incorporates high levels of recycled content, highlighting the complementary roles of renewable carbon and circular material strategies. Prospective scenario modeling underscores the importance of sustainable feedstock selection and process electrification, with sucrose-based routes offering the largest potential for further decarbonization. Overall, the findings demonstrate that PEF is a scalable biopolymer capable of delivering substantial climate benefits while supporting circularity objectives. By targeting a highly visible consumer application—plastic packaging—this transition amplifies the societal impact of adopting renewable carbon materials. The study provides actionable insights for policymakers, industry stakeholders, and sustainability practitioners working to advance a more resilient, renewable, and consumer-recognizable plastics economy.