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Other literature type . 2023
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Article . 2023
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Claim

Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 20 Jan 2023 English Publisher:MDPI AGJournal:Separations, volume 10, page 73 (eissn: 2297-8739, Copyright policy )
Authors: Kateřina Veselá; Zora Mělková; Nikita Abramenko; Zdeněk Kejík; Robert Kaplánek; Petr Dytrych; Alla Sinica; +3 Authors

doi: 10.3390/separations10020073

Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication

Abstract

SARS-CoV-2 is a serious viral pathogen, and agents that inhibit its replication are in high demand. In the present work, we prepared two novel tryptanthrin derivates bearing a thiosemicarbazone moiety as potential antiviral agents. Both compounds displayed potent chelation activity against Fe(III/II) ion-associated COVID-19. The molecular docking results suggest that the compounds can display significant affinity towards SARS-CoV-2 papain-like proteases and SARS-CoV-2 main proteases. In addition, administering T8H-TSC can repress viral replication in the used model (Vero cells). Moreover, the therapeutic potential of the prepared compounds was predicted and analysed in terms of Lipinski’s rules, drug-likeness and drug score.

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Keywords

SARS-CoV-2, Physics, QC1-999, phaitanthrin A, molecular docking, antiviral, thiosemicarbazone, Chemistry, chelation, tryptanthrin, QD1-999, tryptanthrin; phaitanthrin A; thiosemicarbazone; SARS-CoV-2; antiviral; chelation; molecular docking

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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