Human-Machine Interfaces (HMI) allow users to interact with different devices such as computers or home elements. A key part in HMI is the design of simple non-invasive interfaces to capture the signals associated with the user’s intentions. In this work, we have designed two different approaches based on Electroencephalography (EEG) and Electrooculography (EOG). For both cases, signal acquisition is performed using only one electrode, which makes placement more comfortable compared to multi-channel systems. We have also developed a Graphical User Interface (GUI) that presents objects to the user using two paradigms—one-by-one objects or rows-columns of objects. Both interfaces and paradigms have been compared for several users considering interactions with home elements.