Adobe constructions were widespread in the ancient world, and earth was one of the most used construction materials in ancient times. Therefore, the preservation of adobe structures, especially against seismic events, is nowadays an important structural issue. Previous experimental tests have shown that the ratio between mortar and brick mechanical properties (i.e., strength, stiffness and elastic modulus) influences the global response of the walls in terms of strength and ductility. Accurate analyses are presented in both the case of unreinforced and reinforced with fiberglass mesh when varying the mechanical properties of the materials composing the adobe masonry structure. The main issues and variability in the behavior of seismic resisting walls when varying the mechanical properties are herein highlighted. The aim of the overall research activity is to improve the knowledge about the structural behavior of adobe structural members unreinforced and reinforced with fiberglass mesh inside horizontal mortar joints.