Auer-Kleiner1 have found that the administration of morphine of definite dosage to dogs, in which the pancreas had been injured experimentally, caused a very marked rise in the blood sugar, lasting several hours. The administration of opium and its derivatives in the treatment of diabetes mellitus has been a common practice for many years. Many noted observers ascribe beneficial results to this agent. Even today opiates are commonly used in diabetes, particularly in painful conditions, which often complicate this disease.The observations of Auer and Kleiner are therefore of interest and importance, not only from the standpoint that the administration of morphine to diabetic suspects might (in a very simple manner) give a clue as to the existence of the disease, but they would throw light also on two other phases; namely, (I) the relation of glycosuria to pancreatic disorders; (2) the effect of morphine on the course of the hyperglycemia in diabetes. In other words, if morphine is capable of superinducing ...