The works of a large number of investigators have shown that under ordinary conditions the cleavage of urotropin into its components, formaldehyd and ammonia, takes place only in the urinary tract and in other acid media. In the neutral tissue fluids this cleavage does not take place.During their work on infectious abortion in cattle, Mohler and Traum1 fed urotropin to cows for the purpose of ascertaining whether this substance would pass into the udder as formaldehyd as stated by Klein.2 In a number of tests on 5 cows that received from 10 to 80 grams of urotropin per day, the milk contained urotropin but no formaldehyd.In his studies on acid intoxication, Szili3 found that the alkalinity of the blood of rabbits, dogs and sheep could be appreciably lowered by the intravenous injection of 0.6 per cent, hydrochloric acid. Insofar as the cleavage of urotropin in the urinary tract is probably brought about or assisted by the acid phosphates present it seemed reasonable to suppose that this cleavage might als...