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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Name: Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer
Keywords: Adult, Protein Disulfide-Isomerases, 610, Down-Regulation, Gene Expression, Uterine Cervical Neoplasms, Kaplan-Meier Estimate, Protein Disulfide-Isomerases/metabolism, survival, Disease-Free Survival

descriptionPublicationkeyboard_double_arrow_right Article 19 Aug 2013 Korea (Republic of) Publisher:Informa UK LimitedJournal:Biomarkers, volume 18, pages 573-579 (issn: 1354-750X, eissn: 1366-5804,

Authors: Chung, Hyunsoo; Cho, Hanbyoul; Perry, Candice; Song, Jaekyung; Ylaya, Kris; Lee, Heejeong; Kim, Jae-Hoon;

doi: 10.3109/1354750x.2013.827742

pmid: 23957851

Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

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Abstract

We investigated the clinical significance of ERp57 in the progression of cervical cancer.mRNA and protein expression of ERp57 in cervical neoplasias were examined.ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

Country

Korea (Republic of)

Related Organizations

National Institute of Health
Pakistan
Yonsei University
Korea (Republic of)
National Institutes of Health
United States
Center for Cancer Research
United States
Catholic University of Korea
Korea (Republic of)

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Keywords

Adult, Protein Disulfide-Isomerases, 610, Down-Regulation, Gene Expression, Uterine Cervical Neoplasms, Kaplan-Meier Estimate, Protein Disulfide-Isomerases/metabolism, survival, Disease-Free Survival, Young Adult, Uterine Cervical Neoplasms/mortality, Humans, Uterine Cervical Neoplasms/metabolism*, Protein Disulfide-Isomerases/genetics*, Aged, Neoplasm Staging, Neoplastic, Uterine Cervical Neoplasms/pathology, tissue microarray, Middle Aged, Prognosis, Uterine Cervical Dysplasia, Cervical Intraepithelial Neoplasia/mortality, Gene Expression Regulation, Neoplastic, Cervical Intraepithelial Neoplasia/metabolism*, Protein Transport, Cervical Intraepithelial Neoplasia/pathology, Gene Expression Regulation, Tissue Array Analysis, immunohistochemistry, Multivariate Analysis, Cervical cancer, Female, ERp57, Gene Expression*

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