The study investigated the influence of adaptability and organisational work skills on entrepreneurial capabilities among technical college graduates in South-South Nigeria. Two research questions were raised and two hypotheses formulated and tested at 0.05 level of significance. A causal comparative research design was adopted for the study. The population of this study comprises a total of 9,658 graduate in all the government owned Technical Colleges in South-South Nigeria for the 2022/2023 session. The sample size of the study consists 340 technical college graduates and 26 principals from 12 technical colleges selected from the six states in South-South Nigeria. Multistage sampling procedure was used in the study. Data for this study were collected using questionnaire. The validity and reliability of the instrument were determined using internal consistency method and a reliability coefficient obtained were: 0.80 for Adaptability Work Skills scale, 0.85 for Organizational Skills scale and 0.87 for Entrepreneurial capabilities Scale.. Copies of the instruments were administered to 370 technical colleges graduates and principals, retrieved and used for data analysis. Pearson’s coefficient of determination was used to answer the research questions and the hypotheses were tested using linear regression statistics at 0.05 level of significance. The findings of the study revealed that there was a significant relationship between adaptability work skills and the entrepreneurial capabilities of technical college graduates in South-South Nigeria; and that there was a significant relationship between organizational work skills and the entrepreneurial capabilities of technical college graduates in South-South Nigeria. It was recommended on the basis of the findings that the government and educational institutions should organize regular entrepreneurship workshops, seminars, and mentorship programs for technical college students.