Clinical prediction models have the potential to improve health care by supporting earlier diagnosis, guiding treatment decisions, and enabling more personalised care. Yet despite the rapid growth of research in prediction modelling, only a small proportion of models are ultimately used in clinical practice. This book addresses that gap by guiding readers from defining a clinical problem and identifying or developing suitable models to evaluating their real-world impact and implementing prediction model–based innovations in health care. Published by Maastricht University Press as a diamond open-access book, it is freely available online worldwide, with an affordable print-on-demand edition for readers who prefer a physical copy.