In the present study, the In vitro antibacterial activity and In vivo anti- bacterial, anti-inflammatory, and wound healing activity of the leaf extract in solvents ethanol and aqueous extracts of the selected plant Lantana camara . The synthesis of silver nanoparticles using aqueous extract of fresh leaves of Lantana camara as bio reducing agents. This method allowed the synthe- sis of nanoparticles which was confirmed by UV-Visible spectroscopy, FTIR, particle size, and zeta potential. Anti-bacterial activity of ethanol and aque- ous leaf extract of Lantana camara was separately tested for gram-positive bacteria Staphylococcus aureus and gram-negative bacteria Escherichia coli . Again anti-bacterial activity of Lantana camara mediated synthesis silver nanoparticles was tested by disc diffusion assay against standard organ- isms like Escherichia coli and staphylococcus aureus bacteria and in-vivo stud- ies designed to evaluate the carrageenan-induced paw edema and Excision wound model activities of ethanol and aqueous extract of leaf of Lantana camara Linn. The ethanol and aqueous extracts of leaves give positive for all the phytochemical constituents etc. The particle size of silver particles pre- pared in all conditions was in the range of 2657.2nm. The Zeta potential of silver nanoparticles was found to be 0.3mv so it indicates the dispersion and stability.