Biologically active heterocyclic compounds comprise of largest & manifold family of organic compounds. These compounds include Quinolines, Quina- zolines, Aminoquinolines, etc and their derivatives. They exhibit multi- faceted biological properties like analgesic, anti-inflammatory, anticonvul- sant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. Biologically active heterocyclic compounds are considered to be important as they are highly utilized pharmacological molecules. These compounds have various physiological significance too. This review sum- marizes chemical characteristics, possible synthetic routes & various bio- activities of quinazolines.