Simulation-based training is used to improve learners’ skills and enhance their knowledge. Recently, virtual reality technology has been exploited in simulation mainly for training purposes, to enable learning while performing simulated activities that are dangerous or even impossible to be simulated in the real world. In this context, we present a simulation-based firefighter training for an earthquake scenario developed in collaboration with national Italian firefighters rescue units (Italian “Istituto Superiore Antincendi”). The proposed training model is based on a virtual reality solution and foresees a novel interaction and game model developed specifically for training first-responders. The simulator environment is a head-mounted display where the learner interacts with objects and performs specific tasks. The performed test show that the use of virtual reality can improve the effectiveness of training. Indeed, trainees show a better perception of the scene which is reflected in a faster response in the real situation. The proposed training system can help the firefighter by providing adequate information on how to deal with risks.