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Biotransformation of phthalazine byFusarium moniliformeandCunninghamella elegans

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1999Publisher:Informa UK LimitedJournal:Mycologia, volume 91, pages 114-116 (issn: 0027-5514, eissn: 1557-2536,

Authors: Sutherland, John B.; Freeman, James P.; Williams, Anna J.; Deck, Joanna;

doi: 10.1080/00275514.1999.12060998 , 10.2307/3761198

Biotransformation of phthalazine byFusarium moniliformeandCunninghamella elegans

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Abstract

Fusarium moniliforme and Cunninghamella elegans were grown in fluid Sabouraud medium at 28 C. They were dosed with 6.2 mM phthalazine and then incubated for 3 d with shaking at 125 rpm. After extraction with ethyl acetate, the metabolites were purified by HPLC and identified by the UV/visible, mass, and NMR spectra. The results show that F mo- niliforme oxidized about 42% of the phthalazine to 1(2H)-phthalazinone (= 1-hydroxyphthalazine) and that C. elegans oxidized about 6% of the phthalazine to a novel metabolite, phthalazine N-oxide (= phthalazine 2-oxide).

Related Organizations

United States Food and Drug Administration
United States
National Center for Toxicological Research
United States

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