New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017 Serbia, Serbia, Belgium English Publisher:National Library of SerbiaJournal:Journal of the Serbian Chemical Society, volume 82, pages 267-275 (issn: 0352-5139, eissn: 1820-7421,

Copyright policy )Funded by:EC | MAGBIOVIN, MESTD | Rational design and synth...

Authors: Baroud Afya A; Mihajlović-Lalić, Ljiljana E; Stanković Dalibor E; Kajzerberger Marijana; Van Hecke Kristof; Grgurić -Šipka Sanja; Savic Aleksandar;

doi: 10.2298/jsc170109025b

handle: 1854/LU-8551397

New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

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Abstract

A new Ru(II) bipyridyl complex with O4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were > 300 and 177.63?2.28 ?M for the A549 and K562 cells, respectively.

Countries

Serbia, Serbia, Belgium

Related Organizations

University of Belgrade, Institute of Nuclear Sciences Vinča
Serbia
University of Belgrade, Faculty of Chemistry
Serbia
University of Belgrade
Serbia
Ghent University
Belgium

Keywords

IRON(II), biological study, CANCER, X-ray, CISPLATIN, metal complex, Chemistry, biological study: DIPICOLINIC ACID, CHEMISTRY, redox properties, characterization, QD1-999

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