Background and Aims: Diabetes mellitus affects approximately 101 million individuals in India. The Comprehensive Diabetes Care (CDC) programme - an Ayurveda-based structured intervention combining Panchakarma therapy with supervised dietary modification — has been implemented across multiple clinic sites in Maharashtra as an integrative approach for type 2 diabetes mellitus (T2DM) management. All prior published evidence is restricted to single-site retrospective studies with fewer than 200 patients. This study provides the first large-scale, multi-site, real-world evaluation of CDC programme outcomes across 16 clinics in the Vidharbha region of Maharashtra, India.