Background:-Fasting in the month of Ramadan induces metabolic changes that may influence glucose metabolism and cardiovascular parameters in both diabetic and non-diabetic persons. This study was designed to examine the effects of Ramadan fasting on blood glucose, blood pressure, and Body Mass Index (BMI) in diabetic patients and healthy controls. Methods:-This study was conducted at the Department of Physiology, University of Karachi from 17 February to 18 March 2026. 40 participants (20 diabetic patients and 20 healthy controls, aged 20-40 years) were included after informed consent. Demographic and lifestyle factors data were collected using a questionnaire. Fasting blood glucose, blood pressure, and BMI were measured. Fasting blood glucose was assessed after 8-10 hours of fasting using a glucometer (On Call EZ II). Data was analysed using MS Excel, and t-tests were applied with p < 0.05 considered significant.