Nursing education in Nigeria is faced with a lot of challenges. The aim of the study was to identify the teacher-relatedchallenges confronting undergraduate nursing education as perceived by nursing students in universities in south-east Nigeria. Descriptive cross sectional design was used for this study. A sample size of 367 was used which was made up of the students from second year to fifth year levels of the Nursing Program. Multistage sampling technique was used and the instrument for data collection was a questionnaire. Descriptive and inferential statistics were used for data analysis. Findings from the study showed thatteacher-related challenges as perceived by the students included inadequate teaching styles among nurse educators, mean = 1.87,insufficient number of nurse educators, mean = 2.04, low motivation to teach among nurse educators, mean = 1.96, excess workload for nurse educators, mean = 2.27 andlack of nurse educators to change teaching methods to meet the needs of learners, mean = 1.87. There was no significant difference in teacher-relatedchallenges experienced by undergraduate nursing students across the Universities in southeast as the p-value was 0.389.Also the demographic variables of the students had no significant influence on their perception of the teacher-related challenges. In conclusion, the teacher-related challenges as perceived by university nursing students in South-East Nigeria were associated with deficiencies. Recommendationswere given based on the findings from the study