E-cigarettes, often perceived as a safer alternative to traditional smoking, have rapidly gained popularity worldwide. While much attention has been focused on their respiratory and cardiovascular effects, the dermatological implications of e-cigarette use remain underexplored. This article delves into the potential skin-related manifestations associated with vaping, drawing attention to conditions such as contact dermatitis, exacerbation of pre-existing skin disorders, and delayed wound healing. Additionally, we examine the role of chemical components in e-cigarette aerosols, such as propylene glycol, glycerin, and flavoring agents, which may contribute to skin irritation and inflammation. Emerging evidence also suggests a possible link between vaping and systemic effects that impact skin health, including altered immune responses and microvascular changes. By shedding light on these dermatological concerns, this review underscores the need for increased awareness among dermatologists, clinicians, and e-cigarette users. Further research is essential to establish definitive causal relationships and develop targeted interventions for managing these conditions.