Every facet of contemporary society is impacted by the benefits and influence of science. In todays society, chemistry is essential to satisfying peoples needs and desires, and it has become a major human endeavor. The basis for all other sciences is chemistry. Learning new information and abilities as well as comprehending the relationships that relate the problems solution to it are the main objectives of chemistry education. The complexity of chemistry instruction at the upper secondary level has increased. This studys primary goal was to identify the difficulties chemistry students have in their studies and offer suggestions for improving their performance in upper secondary school. In the Thoothukudi district of Tamilnadu, India, 200 higher secondary students who were all taking chemistry as one of their subjects participated in the research. The findings showed that higher secondary pupils have more complex comprehension issues with chemistry ideas. Based on the students class level (Standard XI and XII) and location, there was no discernible variation in the challenges they faced when learning physics nevertheless, there were discernible disparities based on the gender.