This case report describes the successful management of a 50-year-old male patient with septic shock following a right tibia external fixation surgery, who was subsequently scheduled for an above knee amputation. The patient presented with hypoxia, hypotension, and required intubation in intensive care unit. In addition, the patient was placed on a noradrenaline infusion due to persistent hypotension. Laboratory investigations revealed thrombocytopenia, elevated procalcitonin levels, increased C-reactive protein, elevated myoglobin levels, and elevated D-dimer levels. Given the patients critical condition, an ultrasound-guided anterior sciatic nerve block and femoral nerve block were performed for surgery. This case report discusses the successful perioperative management of the patients septic shock and the potential role of regional nerve blocks in such critically ill patients.