Introduction: Nitrous oxide (N2O), also dubbed the laughing gas or proto, is a gas used therapeutically in the medical field. However, a recreational trend has emerged, involving the inhalation of N2O from culinary capsules or canisters. Clinical Case: This involves a 23-year-old patient, Hospitalized for psychomotor agitation, the patient has a history of cardiac arrest following extensive inhalation of laughing gas. The patient presented with a manic syndrome that resolved within 2 days. Biological tests returned normal results, including vitamin B12. Brain MRI revealed bilateral bi-fronto-parietal cortical cerebral atrophy. The patient underwent a neurological etiological assessment, which came back normal. Discussion: The majority of literature reviews on the psychiatric complications of NO2 use have indicated that the most frequent symptoms are delirium, hallucinations, and confusion. The prognosis is often favorable, with symptoms typically resolving under antipsychotic treatment. Conclusion: The consumption of nitrous oxide is a recreational practice that is on the rise, and especially among young people. With easy access and low cost.Cases of intoxication are increasing with serious medical complications which can lead to death, regardless of the type of exposure.