Polo like kinase 4 (PLK4) is a serine/threonine-protein kinase that localizes to centrioles and regulates centriole duplication during the cell cycle. Overexpression of PLK4 causes centrosome amplification, and its knockdown leads to loss of centrosomes. In colorectal cancer (CRC) cells treated with ETC-1922159, PLK4 was found to be down regulated along with other genes. A recently developed search engine ranked combinations of PLK4-X (X, a particular gene/protein) at 2nd order level after drug administration. Some of these combinations have been tested in wet lab, however many have been pointed out by the search engine that are yet to be explored/tested. These rankings reveal which PLK4-X combinations might be working synergistically in CRC. In this research work, I cover combinations of PLK4 with possible members of aurora kinase (AURK), centrosomal protein (CEP), ubiquitin specific peptidase (USP), E2F transcription factor (E2F), epithelial cell transforming 2 (ECT2), STIL centriolar assembly protein (STIL), cell division cycle (CDC), cell division cycle associated (CDCA), cyclin dependent kinase (CDK), forkhead box (FOX), kinesin family member (KIF) and small nucleolar RNA host gene (SNHG) family.