TQM is a general philosophy of management that attempts to enhance competitive advantage of organizations, This paper aims to investigate the impact of total quality management on competitive advantage of pharmaceutical manufacturing companies in Jordan. The data are collected from mid- to senior-level managerial employees of pharmaceutical manufacturing companies in Jordan. The data were analyzed using correlation and multiple regression analyses. The results indicate that, there is effect of the TQM practices on competitive advantage; customer focus has the highest impact on competitive advantage followed by People management and Leadership subsequently. And thus, total quality management is strategically and tactically important for gaining a competitive advantage. Therefore, organizations should be committed to TQM practices and their successful implementation.