Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period

descriptionPublicationkeyboard_double_arrow_right Article 20 Oct 2017Publisher:Biology Centre, AS CRJournal:Folia Parasitologica, volume 64 (issn: 0015-5683, eissn: 1803-6465,

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Authors: Marketa, Rezkova; Jan, Kopecky;

doi: 10.14411/fp.2017.032

pmid: 29063857

Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period

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Abstract

Tumour necrosis factor (TNF) plays a central role in the inflammatory process. In the skin, it contributes to immune containment of tick-transmitted pathogens like Borrelia burgdorferi. In the saliva of some tick species, active compounds are present that inhibit detection of TNF in specific ELISA. We compared the presence of anti-TNF activity in saliva or salivary gland extract from 11 tick species from the family Ixodidae and demonstrated it in genera Ixodes Latreille, 1795 and Haemaphysalis Koch, 1844. Analysis of anti-TNF activity in Ixodes ricinus (Linnaeus, 1758) saliva during the feeding period showed that it is present in the late, rapid phase of engorgement. Significance of anti-TNF activity for tick feeding and transmission of tick-borne pathogens is discussed.

Related Organizations

Sewanee: The University of the South
United States
University of South Bohemia in České Budějovice
Czech Republic

Keywords

Ixodes, Tumor Necrosis Factor-alpha, Animals, Feeding Behavior, Saliva

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