Mexico is one of the two centers of diversity of the genus Ruehssia, surpassed only by Brazil. However, the knowledge of the genus is still far from complete, and there are regions that have not been adequately reviewed. This paper presents a revision of Ruehssia for the state of Sinaloa, Mexico, and proposes two new species from the state. Six species of Ruehssia were recorded for the area, including the two newly described: Ruehssia ovotaurina, distributed from Sinaloa and Durango, and R. tufii, which is endemic to the state. With these two new additions, Mexico has 41 species of Ruehssia. The species R. coulteri had been previously reported for the state, but was not found in herbarium material, so it is not included in this review. Three of the six Ruehssia species in Sinaloa are consumed as food by the local population, and three of them meet the requirements for inclusion in the IUCN Vulnerable category or higher. Thus, the genus should be considered a conservation priority in the state.