Recent discovered technologies have exposed many new theories and possibilities to improve our standard of living. Medical assistance has been a major research topic in the past, many efforts were put in to simplify the process of following treatment prescriptions. This paper summarizes the work done in developing LoRa driven medical adherence system in order to improve medicine adherence for elderlies. The designed system is composed of two sections; embedded hardware device for the use of patients at home and Web application to manage all patients along with their medicines and keep track of their medicine intake history. LoRa wireless communication technology is used for connecting all embedded devices with a central gateway that manages the network. Hardware and software tests have been conducted and showed great performance in terms of LoRa network range and latency. In short, the proposed system shows promising method of improving medicine adherence.