The design of a secure, intelligent laboratory that incorporates internet of things (IoT) devices and applications is a complex process. One of the main goals is to create a process monitoring system that can collect and analyze data from connected devices such as temperature and pressure sensors, smart locks, and access control systems. This system must operate in real time to ensure that equipment is within reference values. This reduces the risk of contamination and increases reliability. In addition, computer network security is paramount and it is imperative that certain measures such as encryption, multi-factor authentication, and intrusion detection systems are implemented. These measures help to ensure the safety and security of critical information and protect against potential risks. Physical security is also essential to protect scientific equipment and data. This paper provides a comprehensive overview of the critical factors involved in designing a secure, intelligent laboratory. It discusses the benefits of the integration of IoT devices and applications, and the security challenges that must be addressed. The paper also provides recommendations for designing and implementing a secure smart lab.