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Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994Publisher:S. Karger AGJournal:Cytogenetic and Genome Research, volume 66, pages 164-166 (issn: 1424-8581, eissn: 1424-859X,

Authors: Jänne, P. A.; Dutra, A. S.; Dracopoli, N. C.; Charnas, L. R.; Puck, J. M.; Nussbaum, R. L.;

doi: 10.1159/000133691

pmid: 8125013

Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34

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Abstract

The 75-kDa (type II) inositol polyphosphate-5-phosphatase, originally described in platelets, is one of at least three known enzymes capable of dephosphorylating inositol-1,4,5-trisphosphate (IP<sub>3</sub>) to inositol-1,4-bisphosphate (IP<sub>2</sub>). To further characterize these enzymatic forms, we have mapped the gene (INPP5B) coding for the 75-kDa type II enzyme. Using a combination of human × rodent somatic cell hybrids and fluorescence in situ hybridization, we have determined that this gene maps to human chromosome band 1p34.

Related Organizations

University of Pennsylvania
United States
National Human Genome Research Institute
United States

Keywords

Base Sequence, Inositol Polyphosphate 5-Phosphatases, Molecular Sequence Data, Chromosome Mapping, Hybrid Cells, Phosphoric Monoester Hydrolases, Cricetulus, Chromosomes, Human, Pair 1, Cricetinae, Animals, Humans, Female, In Situ Hybridization, Fluorescence, DNA Primers

5 Research products, page 1 of 1

Type II inositol 1,4,5-trisphosphate 5-phosphatase
2017IsRelatedTo
Type II inositol 1,4,5-trisphosphate 5-phosphatase
2017IsRelatedTo
Type II inositol 1,4,5-trisphosphate 5-phosphatase
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
Inositol polyphosphate 5-phosphatase II splice variant
2017IsRelatedTo

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