An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:S. Karger AGJournal:Cytogenetic and Genome Research, volume 92, pages 204-208 (issn: 1424-8581, eissn: 1424-859X,

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Authors: Shulenin, S.; Schriml, L. M.; Remaley, A. T.; Fojo, S.; Brewer, B.; Allikmets, R.; Dean, M.;

doi: 10.1159/000056903

pmid: 11435688

An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus

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Abstract

We characterized a new human ATP-binding cassette (ABC) transporter gene that is highly expressed in the liver. The gene, ABCG5, contains 13 exons and encodes a 651 amino acid protein. The predicted protein is closely related to the Drosophila white gene and a human gene, ABCG1, which is induced by cholesterol. This subfamily of genes all have a single ATP-binding domain at the N-terminus and a single C-terminal set of transmembrane segments. ABCG5 maps to human chromosome 2p21, between the markers D2S117 and D2S119. The abundant expression of this gene in the liver suggests that the protein product has an important role in transport of specific molecule(s) into or out of this tissue.

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King’s University
United States

Keywords

Genetic Markers, Lipoproteins, Molecular Sequence Data, Exons, Introns, Protein Structure, Tertiary, Drosophila melanogaster, Liver, Organ Specificity, Chromosomes, Human, Pair 2, Multigene Family, Animals, Humans, ATP-Binding Cassette Transporters, Amino Acid Sequence, RNA Splice Sites, ATP Binding Cassette Transporter, Subfamily G, Member 5, Cloning, Molecular, Phylogeny, ATP Binding Cassette Transporter, Subfamily G, Member 1

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