Artificial Intelligence of Things (AIoT) is one of the next big concepts to support societal changes and economic growth, being one of the fastest growing ICT segments. A specific challenge is to leverage existing technology strengths to develop solutions that sustain the European industry and values. The ongoing ΝΕΜΟ (“Next Generation Meta-Operating System”) EU-funded project intends to establish itself as the “game changer” of the AIoT-Edge-Cloud continuum by introducing an open source, modular and cybersecure meta-operating system, leveraging on existing technologies and introducing novel concepts, methods, tools, testing and engagement campaigns. NEMO will bring intelligence closer to the data and make AI-as-a-Service an integral part of network self-organisation and micro-services execution orchestration. Its widespread penetration and massive acceptance will be achieved via new technology, pre-commercial exploitation components and liaison with open-source communities. By defining a modular and adaptable mOS (meta-OS) architecture together with building blocks and plugins the project will “address” current and future technological and business needs.