PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

descriptionPublicationkeyboard_double_arrow_right Article 19 Mar 1993 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 259, pages 1,763-1,766 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Rohan, P.; Davis, P.; Moskaluk, C.; Kearns, M.; Krutzsch, H.; Siebenlist, U.; Kelly, K.;

doi: 10.1126/science.7681221

pmid: 7681221

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

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Abstract

Tyrosine phosphorylation of proteins is required for signal transduction in cells and for growth regulation. A mitogen-induced gene ( PAC-1 ) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

Related Organizations

National Institute of Allergy and Infectious Diseases
United States
National Cancer Institute
United States
National Institutes of Health
United States

Keywords

Cell Nucleus, Cytoplasm, Sequence Homology, Amino Acid, Molecular Sequence Data, Dual Specificity Phosphatase 2, Fluorescent Antibody Technique, Blotting, Northern, Cell Line, Mice, Organ Specificity, Animals, Humans, RNA, Amino Acid Sequence, Protein Phosphatase 2, Mitogens, Protein Tyrosine Phosphatases, Conserved Sequence, Immunosorbent Techniques, Signal Transduction

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