Molecular Cloning of a Gene Sequence Regulated by Nerve Growth Factor

descriptionPublicationkeyboard_double_arrow_right Article 26 Jul 1985 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 229, pages 393-395 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Levi, A.; Eldridge, J.; Paterson, B.;

doi: 10.1126/science.3839317

pmid: 3839317

Molecular Cloning of a Gene Sequence Regulated by Nerve Growth Factor

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Abstract

Nerve growth factor (NGF) is essential for the development and differentiation of sympathetic or sensory neurons. A complementary DNA was cloned that corresponds to a gene sequence induced more than 50-fold in a cultured target cell line of pheochromocytoma cells (PC12 cells) 5 hours after the addition of NGF. The induced messenger RNA encodes a 90,000-dalton polypeptide that may represent one of the primary events in NGF-induced differentiation of neurons.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan
National Cancer Institute
United States

Keywords

Base Sequence, Adrenal Gland Neoplasms, Nucleic Acid Hybridization, DNA, Pheochromocytoma, Actins, Cell Line, Rats, Gene Expression Regulation, Genes, Animals, Nerve Growth Factors, RNA, Messenger, Rabbits, Cloning, Molecular, Chickens

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