Equine Infectious Anemia Virus  gag  and  pol  Genes: Relatedness to Visna and AIDS Virus

descriptionPublicationkeyboard_double_arrow_right Article 07 Feb 1986 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 231, pages 589-594 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Stephens, R.; Casey, J.; Rice, N.;

doi: 10.1126/science.3003905

pmid: 3003905

Equine Infectious Anemia Virus gag and pol Genes: Relatedness to Visna and AIDS Virus

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Abstract

Comparison of HTLV-III, the putative AIDS virus, with other related viruses, may help to reveal more about the origin of AIDS in humans. In this study, the nucleotide sequence of the gag and pol genes of an equine infectious anemia virus (EIAV) proviral DNA clone was determined. The sequence was compared with that of HTLV-III and of visna, a pathogenic lentivirus of sheep. The results show that these viruses constitute a family clearly distinct from that of the type C viruses or the BLV-HTLV-I and -II group. Within the family, EIAV, HTLV-III, and visna appear to be equally divergent from a common evolutionary ancestor.

Keywords

Base Sequence, Genes, Viral, Visna-maedi virus, Deltaretrovirus, Mice, DNA, Viral, Animals, Humans, Horses, Codon, Infectious Anemia Virus, Equine

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