Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

descriptionPublicationkeyboard_double_arrow_right Article 22 Mar 1996 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 271, pages 1,723-1,726 (issn: 0036-8075, eissn: 1095-9203,

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Authors: J P, Ridge; E J, Fuchs; P, Matzinger;

doi: 10.1126/science.271.5256.1723

pmid: 8596932

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

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Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan
National Institute of Allergy and Infectious Diseases
United States

Keywords

Cytotoxicity, Immunologic, Male, B-Lymphocytes, T-Lymphocytes, H-Y Antigen, Dendritic Cells, Cytotoxicity Tests, Immunologic, Mice, Inbred C57BL, Mice, Self Tolerance, Animals, Newborn, Immune Tolerance, Animals, Female, Immunization

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