Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

descriptionPublicationkeyboard_double_arrow_right Article 29 Mar 1991 Netherlands English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 251, pages 1,597-1,600 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Gatignol, A.; Buckler-White, A.; Berkhout, B.; Jeang, K.;

doi: 10.1126/science.2011739

pmid: 2011739

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

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Abstract

Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.

Country

Netherlands

Related Organizations

National Institutes of Health
United States
Amsterdam UMC
Netherlands
National Institute of Allergy and Infectious Diseases
United States
National Institute of Health
Pakistan

Keywords

Ribonuclease III, Binding Sites, Base Sequence, Escherichia coli Proteins, Molecular Sequence Data, RNA-Binding Proteins, Trans-Activation Responsive RNA-Binding Protein, Sequence Homology, Nucleic Acid, Endoribonucleases, Gene Products, tat, Escherichia coli, HIV-1, Humans, Nucleic Acid Conformation, RNA, Viral, tat Gene Products, Human Immunodeficiency Virus, Amino Acid Sequence, Carrier Proteins, HIV Long Terminal Repeat, Plasmids

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