From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

descriptionPublicationkeyboard_double_arrow_right Article 11 Apr 2003 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 300, pages 294-295 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Robert L, Strausberg; Stuart L, Schreiber;

doi: 10.1126/science.1083395

pmid: 12690189

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

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Abstract

The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the development of small molecular probes. The probes are useful for activating or inactivating protein functions, thereby providing resources that help discern the functions of gene products in normal and disease cells, as well as in tissues. This initiative includes “ChemBank,” a suite of informatics tools and databases aimed at promoting the development and use of chemical genetics by scientists worldwide. The information generated with such tools should provide a critical link from genomic discovery to drug development.

Related Organizations

Howard Hughes Medical Institute
United States
National Cancer Institute
United States
Harvard University
United States

Keywords

Clinical Trials as Topic, Databases, Factual, Chemistry, Pharmaceutical, Computational Biology, Molecular Probe Techniques, Proteins, Genomics, United States, National Institutes of Health (U.S.), Pharmaceutical Preparations, Drug Design, Molecular Probes, Animals, Combinatorial Chemistry Techniques, Humans, Technology, Pharmaceutical

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