Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Copyright policy )Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Eukaryotes use adenosine triphosphate (ATP)–dependent chromatin-remodeling complexes to regulate gene expression. Here, we show that inositol polyphosphates can modulate the activities of several chromatin-remodeling complexes in vitro. Inositol hexakisphosphate (IP 6 ) inhibits nucleosome mobilization by NURF, ISW2, and INO80 complexes. In contrast, nucleosome mobilization by the yeast SWI/SNF complex is stimulated by inositol tetrakisphosphate (IP 4 ) and inositol pentakisphosphate (IP 5 ). We demonstrate that mutations in genes encoding inositol polyphosphate kinases that produce IP 4 , IP 5 , and IP 6 impair transcription in vivo. These results provide a link between inositol polyphosphates, chromatin remodeling, and gene expression.
- National Institutes of Health United States
- National Institute of Health Pakistan
- National Cancer Institute United States
- Center for Cancer Research United States
Adenosine Triphosphatases, Phytic Acid, Inositol Phosphates, Nuclear Proteins, Chromatin, Recombinant Proteins, Nucleosomes, DNA-Binding Proteins, Adenosine Triphosphate, Gene Expression Regulation, Fungal, Yeasts, Myo-Inositol-1-Phosphate Synthase, RNA, Messenger, Signal Transduction, Transcription Factors
Adenosine Triphosphatases, Phytic Acid, Inositol Phosphates, Nuclear Proteins, Chromatin, Recombinant Proteins, Nucleosomes, DNA-Binding Proteins, Adenosine Triphosphate, Gene Expression Regulation, Fungal, Yeasts, Myo-Inositol-1-Phosphate Synthase, RNA, Messenger, Signal Transduction, Transcription Factors
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