Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus
Copyright policy )Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000–2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998–1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
- National Institute of Infectious Diseases Japan
- Ministry of Health Viet Nam
- National Center for Emerging and Zoonotic Infectious Diseases United States
- Office of Infectious Diseases United States
- National Institute for Public Health and the Environment Netherlands
Male, Adolescent, Genes, Viral, Immunization Programs, Dominican Republic, Molecular Sequence Data, Infant, Haiti, Disease Outbreaks, Mice, Capsid, Child, Preschool, Animals, Humans, Point Mutation, Capsid Proteins, Female, 5' Untranslated Regions, Child, Poliomyelitis
Male, Adolescent, Genes, Viral, Immunization Programs, Dominican Republic, Molecular Sequence Data, Infant, Haiti, Disease Outbreaks, Mice, Capsid, Child, Preschool, Animals, Humans, Point Mutation, Capsid Proteins, Female, 5' Untranslated Regions, Child, Poliomyelitis
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