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Mesenchymal Growth Hormone Receptor Deficiency Leads to Failure of Alveolar Progenitor Cell Function and Severe Pulmonary Fibrosis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 May 2020Publisher:American Thoracic SocietyJournal:D27. CELLULAR RESPONSES INFORMING LUNG REPAIRPublicly fundedFunded by:NIH | Targeting beta-arrestins ..., EC | FIBROSIS, NIH | Matrix Regulation of Pulm... +2 projects

Authors: Xie, Ting; Kulur, Vrishika; Liu, Ningshan; Deng, Nan; Wang, Yizhou; Rowan, Simon Coyle; Yao, Changfu; +9 Authors

doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6385 , 10.1126/sciadv.abg6005

pmid: 34108218

pmc: PMC8189579

Mesenchymal Growth Hormone Receptor Deficiency Leads to Failure of Alveolar Progenitor Cell Function and Severe Pulmonary Fibrosis

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Abstract

Mesenchymal vesicular GHR supports alveolar epithelial progenitor cell renewal and limits lung fibrosis.

Related Organizations

Cedars-Sinai Medical Center
United States
Lung Institute
United States
CEDARS-SINAI MEDICAL CENTER
University College Dublin
Ireland

Keywords

Mice, Alveolar Epithelial Cells, Stem Cells, Animals, Humans, Lung, Research Articles, Idiopathic Pulmonary Fibrosis, Laron Syndrome

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%