Using grey correlation analysis to the relationship between the incidence of liver cancer and drinking water quality in Fujian , Jiangsu , and Guangxi provinces, considering the basic features of the original and the secondary environments in the study areas, the following conclusions can be drawn: liver cancer can be caused by many factors and drinking water may be among the most important ones; minerals (e.g. Ca2+, Mg2+, Mo, Zn, etc. ) needed in drinking water by human body in southeastern coastal areas of China are relatively low; Ca2+ , Cu ,NO2- etc . are closely related to the incidence of liver cancer.