This research article introduces a novel integrated circuit (IC) designed for bioreactor applications catering to multichannel electrochemical sensing. The proposed IC comprises 2x potentiometric, 2x potentiostat, 2x ISFET channels and 1x temperature channel. The potentiostat channel utilizes a current conveyor-based architecture with a programmable mirroring ratio, enabling an extensive measurement range of 114 dB. The potentiometric channel incorporates a customized electrostatic discharge (ESD) protection circuit to achieve ultra-low input leakage in the picoampere range, while the ISFET channel employs a constant-voltage, constant-current topology for accurate pH measurement. Combined with the die temperature sensor, this IC is well-suited for monitoring bioreactions in real-time. Additionally, all channels can be time-multiplexed to a reconfigurable analog backend, facilitating the conversion of input signals into digital codes. The prototype of the IC is fabricated using 0.18 μm standard CMOS technology, and each channel is experimentally characterized. The interface IC demonstrates a peak power consumption of 22 μW.