Providing ubiquitous fifth-generation (5G) connectivity is very appealing to advance a wide range of use cases and industry verticals. However, it is expected that the ultimate capability of 5G networks will only be achievable by a blend of technologies centered around 5G to fulfil the needs for different verticals and use cases. In this regard, this paper presents the key requirements to collectively leverage 5G, artificial intelligence, and cloud computing technologies to enable a smart campus/buildings use case. A comprehensive framework is first presented showing the key enabler constituents of this use case, ranging from the network to cloud and application domains interconnected in a 5G testbed. The description of the individual components in the 5G testbed is then explained. Key technical challenges pertaining to smart campus/buildings use case are then discussed, and potential research directions are outlined.