Application of microcalorimeter energy measurement to biopolymer mass spectrometry

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2001Publisher:Institute of Electrical and Electronics Engineers (IEEE)Journal:IEEE Transactions on Appiled Superconductivity, volume 11, pages 242-247 (issn: 1051-8223,

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Authors: Rabin, M. W.; Hilton, G. C.; Martinis, J. M.;

doi: 10.1109/77.919329

Application of microcalorimeter energy measurement to biopolymer mass spectrometry

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Abstract

We have performed electrospray ionization mass spectrometry using a magnetic-sector mass spectrometer of proteins, detecting the ions with a normal-insulator-superconductor microcalorimeter detector. We emphasize the measurement of ion-impact energy as a way to obtain extra information that is unavailable in normal mass spectrometry. Energy measurements are used to discriminate against erroneous ion-strikes, to resolve ambiguities that cannot be resolved by normal mass spectrometry, and to illustrate some of the performance limits of the current detector design.

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National Institute of Standards and Technology
United States

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