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Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis

HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 01 Apr 2012Publisher:Center for Open ScienceJournal:Current Opinion in HIV and AIDS (issn: 1746-630X,

Authors: uploaded via Dissemin; Christof Geldmacher; Michael Hoelscher; Alimuddin Zumla;

doi: 10.31219/osf.io/w6vm2 , 10.1097/coh.0b013e3283524e32 , 10.17605/osf.io/w6vm2

pmid: 22495739

Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis

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Abstract

Purpose of Review: HIV infection is the main driver of the HIV/tuberculosis (TB) syndemic in southern Africa since the early 1990s, when HIV infection rates started to increase exponentially and TB incidence rates quadruplet simultaneously. Here, we discuss pathogenic mechanisms of HIV-induced CD4 T-cell depletion and their potential impact on immune control of Mycobacterium tuberculosis. Recent Findings: Depletion of effector memory CD4 T cells from the air-tissue interphase, their dysfunctional regeneration and the preferential depletion of MTB-specific CD4 T cells from circulation and from the air-tissue interphase might be key factors for the increased susceptibility to develop active TB after HIV infection. Summary: Early initiation of antiretroviral therapy or the development of an efficacious HIV vaccine would be the best options to reduce morbidity and mortality associated with the HIV/TB syndemic. © Lippincott Williams & Wilkins.

Related Organizations

Ludwig-Maximilians-Universität München
Germany

Keywords

CD4-Positive T-Lymphocytes, AIDS-Related Opportunistic Infections, Coinfection, Life Sciences, HIV Infections, Mycobacterium tuberculosis, Africa, Southern, CD4 Lymphocyte Count, HIV-1, Humans, Tuberculosis

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