<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

A human recessive neurosensory nonsyndromic hearing impairment locus is a potential homologue of the murine deafness (dn) locus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1995Publisher:Oxford University Press (OUP)Journal:Human Molecular Genetics, volume 4, pages 2,391-2,394 (issn: 0964-6906, eissn: 1460-2083,

Authors: Jain, Pawan K.; Fukushima, Kunihiro; Deshmukh, Dilip; Ramesh, Arabandi; Thomas, Elizabeth; Lalwani, Anil K.; Kumar, Subrinder; +8 Authors

doi: 10.1093/hmg/4.12.2391

pmid: 8634715

A human recessive neurosensory nonsyndromic hearing impairment locus is a potential homologue of the murine deafness (dn) locus

- Summary
- Subjects
- Metrics

Abstract

A locus for recessive neurosensory nonsyndromic hearing impairment maps to chromosome 9q13-q21 in two regionally separate consanguineous families from India. Each family demonstrates a LOD score greater than 4.5 to this region. D9S15, tightly linked to the Friedreich's ataxia locus, a region that has been defined with over 1 Mb of YAC contig information and several expressed sequences, is one of the flanking markers. In mice, the deafness (dn) locus maps to mouse chromosome 19 and flanking loci are syntenic to human chromosome 9q11-q21. The dn mouse is a potential model for the hearing impairment found in both these families.

Related Organizations

National Institute of Health
Pakistan
University of Madras
India
National Institute on Deafness and Other Communication Disorders
United States
Laboratory of Molecular Genetics
Poland
National Institutes of Health
United States

Keywords

Male, Consanguinity, Hearing Loss, Sensorineural, Chromosome Mapping, Humans, Female, Genes, Recessive, Chromosomes, Human, Pair 9, Pedigree

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	68
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%