A KIT‐6/poly(acrylic acid‐ethylene glycol dimethacrylate) (KIT‐6/Poly(AA‐EGDMA) nanocomposite was synthesised as an adequate carrier. KIT‐6 as a three‐dimensional cubic symmetric structure was prepared by the sol–gel method. Polymerisation was carried out through the in situ method in which EGDMA was cross‐linked by AA inside KIT‐6 pores. This mesostructure acts as a smart uptake and release of the ibuprofen (IBU) system. Diverse characterisation techniques including Fourier transform infrared spectroscopy, X‐ray powder diffraction, Brunauer–Emmett–Teller, thermal gravimetric, scanning electron microscopy and ultraviolet‐visible spectroscopy were employed to determine the relationship between the carrier nature and drug release performance. The KIT‐6/Poly(AA‐EGDMA) was modified by changing the ratio of the polymer and IBU as well as its time‐loading. The results proved that the KIT‐6/Poly(AA‐EGDMA) has the ability of drug adsorption and slow release in a simulated body fluid.