Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications (issn: 1359-7345, eissn: 1364-548X,

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Authors: Yasui, Yoshizumi; Kinugawa, Tomoyo; Takemoto, Yoshiji;

doi: 10.1039/b907210a

pmid: 19585045

Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton

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Abstract

Synthetic studies on vincorine are described; the conversion of 3-aminoethyl-3-alkyloxindoles to 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles has been achieved through an addition-cyclization sequence, and a fully functionalized key intermediate was constructed with this method.

Related Organizations

Kyoto University
Japan
Tohoku University
Japan

Keywords

Indoles, Vinca Alkaloids

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