The molecular mechanics of mixed lineage leukemia

descriptionPublicationkeyboard_double_arrow_right Article 29 Feb 2016 English Publisher:Springer Science and Business Media LLCJournal:Oncogene, volume 35, pages 5,215-5,223 (issn: 0950-9232, eissn: 1476-5594,

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Authors: Slany, R. K.;

doi: 10.1038/onc.2016.30

pmid: 26923329

The molecular mechanics of mixed lineage leukemia

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Abstract

Mixed lineage leukemia caused by MLL fusion proteins is still a mostly incurable disease. Research on novel treatment strategies has gained momentum in the last years with the elucidation of the molecular mechanisms underlying the transforming potential of these powerful oncoproteins. This review summarizes the recent developments in this area including new attempts to treat MLL in a rational way by exploiting the biochemical vulnerabilities of the leukemogenic process.

Related Organizations

University of Erlangen-Nuremberg
Germany

Keywords

Leukemia, Oncogene Proteins, Fusion, Histone-Lysine N-Methyltransferase, Methyltransferases, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Small Molecule Libraries, Mice, Animals, Humans, Molecular Targeted Therapy, Myeloid-Lymphoid Leukemia Protein

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