SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

descriptionPublicationkeyboard_double_arrow_right Article 23 Aug 2006 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 7, pages 782-788 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Tzur, Yonatan B.; Wilson, Katherine L.; Gruenbaum, Yosef;

doi: 10.1038/nrm2003

pmid: 16926857

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

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Abstract

The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.

Related Organizations

Hebrew University of Jerusalem
Israel
Johns Hopkins University School of Medicine
United States
Johns Hopkins Medicine
United States

Keywords

Nuclear Envelope, Animals, Nuclear Proteins, Models, Biological, Cytoskeleton, Phylogeny, Forecasting, Protein Structure, Tertiary

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